FIG. 2.

Time-dependent MeHg-induced toxicity in C57BL/6 mice.

C57BL/6 mice were treated with 40mg/l MeHg diluted in tap water for 7, 14, or 21 days. After treatments, cerebellar GPx activity (A), plasma cholesterol levels (B), and vertical activity in the open field test (C) were measured. Data are presented as percent of the respective control and expressed as mean ± SEM (n = 8 animals per group). *p < 0.05 compared with the control group (unpaired Student’s t-test). (D) Scatter plot of the relationship between cerebellar GPx activity and total plasma cholesterol levels. Data of GPx activity are derived from (A) and (B), respectively. Pearson’s coefficient: –0.7592 (p < 0.005).