FIG. 5.

Chronic MeHg exposure decreases GPx activity in the cerebellum of C57BL/6 and LDLr^–/– mice.

C57BL/6 and LDLr^–/– mice were treated for 21 days with 40mg/l MeHg diluted in tap water. (A) Cerebellar GPx activity is presented as nmol of NADPH oxidized/mg protein/min and expressed as mean ± SEM (n = 7–10 animals per group). *p < 0.05 compared with the control (non-MeHg treated) group, &p < 0.05 compared with control (non-MeHg treated) LDLr^–/– mice (two-way ANOVA followed by Newman-Keuls post hoc test). (B) Scatter plot of the relationship between cerebellar GPx activity and total plasma cholesterol levels; data are derived from (A) and (1E), respectively. Squares represent C57BL/6 mice and circles represent LDLr^–/– mice. White color represents control and black color represents MeHg-treated animals. Pearson’s coefficient: -0.56 (p < 0.005).