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Tm3 overlays the colitic Cdcs1 QTL. Previous congenic analysis defined Cdcs1 between 87.1 and 131.1 Mbp (solid box), and overlays gpdc1 (dashed box), a mouse QTL which also correlates with spontaneous colitis. T. muris QTL Tm3 (broken line) lies between D3Mit156 (92 Mbp) and D3Mit79 (118 Mbp), outside the location of a previously defined candidate gene NfkB1 (135.1 Mbp). The threshold for suggestive correlation is shown for Tm3 at LOD 2.4.
