Table 1.

GO regulation definitions

GO ID	GO term	GO definition
GO:0050789	Regulation of a biological process	Any process that modulates the frequency, rate extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
GO:0048518	Positive regulation of a biological process	Any process that activates or increases the frequency extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
GO:0048519	Negative regulation of a biological process	Any process that stops, prevents or reduces the extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

Gene Ontology definitions of regulation, positive regulation and negative regulation of biological processes.