Table 2.

Prognostic factors for survival and recurrence

Factor	OS			TTR
	Univeriate	Multivariate		Univeriate	Multivariate
	P	HR (95% CI)	P	P	HR (95% CI)	P
AFP(ng/ml) (≤20 v >20)	0.022		NS	0.003	1.482(1.030-2.132)	0.034
Tumor number (single v multiple)	<0.001	2.803(1.616-4.864)	<0.001	0.011	1.964(1.395-2.766)	0.001
Vascular invasion (yes v no)	<0.001	1.571(1.027-2.401)	0.037	<0.001		NS
Tumor size(cm) (≤5.0 v >5.0)	<0.001	2.552(1.671-3.897)	<0.001	<0.001	1.964(1.395-2.766)	<0.001
TNM stage (I v II- III)	<0.001	1.891(1.223-2.926)	0.004	0.001	1.564(1.092-2.240)	0.015
Peritumoral density (low v high) IL-17RE	<0.001	2.172(1.404-3.361)	<0.001	<0.001	1.721(1.222-2.425)	0.002
Intratumoral density (low v high)
IL-17RE	<0.001		NS	<0.001		NS
Il-17	0.016		NS	<0.001		NS
Combination of IL-17RE &IL-17	<0.001	1.569(1.315-1.873)	<0.001	<0.001	1.433(1.234-1.663)	<0.001

Univeriate analysis: Kaplan-Meier method; multivariate analysis: Cox proportional hazards regression model.

Abbreviations: OS, overall survival; TTR, time to recurrence; HR, Hazard Ratio; CI, confidence interval; AFP, alpha fetoprotein; TNM, tumor-node-metastasis;IL-17RE, interleukin-17receptor E; NA, not adopted; NS, not significant.