Table 1.
Effects of hypothermia and haemodilution on coagulation measured with free oscillation rheometry (FOR)
| |
Temperature |
Solution |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| Variable | 37°C | 33°C | Undiluted | RA | HES | ||||
| COT1 (s) |
18.1 |
21.2 |
** |
17.6 |
20.1 |
** |
21.3 |
*** |
|
| COT2 (s) |
58.3 |
68.8 |
*** |
48.5 |
55.5 |
** |
86.7 |
** |
† |
| G'max Fib1 (Pa) |
716 |
613 |
*** |
983 |
617 |
*** |
395 |
*** |
††† |
| G'max Fib2 (Pa) |
31.7 |
24.5 |
*** |
43.3 |
29.5 |
*** |
11.5 |
*** |
††† |
| G'max Fib1-2 (Pa) | 685 | 589 | ** | 940 | 587 | *** | 383 | *** | ††† |
Effects on coagulation of hypothermia (33°C versus 37°C) and 33% haemodilution with RA or HES compared to undiluted blood, presented as estimated marginal means. COT1 and COT2 are coagulation time 1 and 2, respectively. The maximal clot strength is presented as G'max for Fib1 (without platelet inhibition) and G'max for Fib2 (with platelet inhibition). Platelet-dependent clot strength is presented by the difference between G'max for Fib1 and that for Fib2, denoted as G'max Fib1-2.
** and *** stands for p < 0.01 and p < 0.001, respectively, when the two temperatures were compared or when diluted blood (RA or HES) was compared to undiluted blood. †† and ††† stands for p < 0.01 and p < 0.001, respectively, when haemodilution with RA was compared to HES. See text for details on interactions. N = 10.