Table 3.
Effects of added coagulation factors on coagulation measured with free oscillation rheometry (FOR)
| |
Coagulation Factor |
|||||
|---|---|---|---|---|---|---|
| Variable | Control | Fibrinogen | Fibrinogen + FXIII | |||
| COT1 (s) |
20.7 |
19.4 |
|
19.0 |
** |
|
| COT2 (s) |
71.1 |
55.2 |
*** |
53.1 |
*** |
|
| G'max Fib1 (Pa) |
506 |
585 |
** |
606 |
** |
|
| G'max Fib2 (Pa) |
20.5 |
31.0 |
*** |
36.3 |
*** |
†† |
| G'max Fib1-2 (Pa) | 485 | 554 | ** | 570 | ** | |
Effects on coagulation of the coagulation factors fibrinogen, fibrinogen with factor XIII (Fibrinogen + FXIII) or no addition of coagulation factor (Control). Data are estimated marginal means. COT1 and COT2 are coagulation time 1 and 2, respectively. The maximal clot strength is presented as G'max for Fib1 (without platelet inhibition) and G'max for Fib2 (with platelet inhibition). Platelet-dependent clot strength is presented by the difference between G'max for Fib1 and that of Fib2, denoted as G'max Fib1-2. ** and *** stands for p < 0.01 and p < 0.001, respectively, when the addition of coagulation factor was compared to the control group. †† and ††† stands for p < 0.01 and p < 0.001, respectively, when the addition of fibrinogen alone was compared to the addition of fibrinogen with FXIII. See text for details on interactions. N = 10.