Figure 2. Effect of sEH over-expression on endothelium-dependent cerebral blood flow in male mice.

A. Representative traces illustrating reduced LDP response to 1 µM ACh stimulation in Tie2-hsEH compared to WT mice over time. B. Quantification of laser Doppler perfusion (LDP) shows that perfusion is significantly reduced in Tie2-hsEH mice compared to WT. (n = 9 WT, n = 8 Tie2-hsEH, P<0.05). C. Schematic representation of cranial window preparation.