Fig.2.

(a) Electroencephalography (EEG) and magnetoencephalography (MEG) waveforms at clinical seizure onset, about 41 sec after EEG/MEG seizure onset.

(b) Result of dipole analysis with/without movement compensation (MC) of 4 spikes enclosed by the dotted line in Fig. 2a. Top view images of spikes (upper panel), representative spike waveforms (middle left), MEG contour map (middle right), and axial and coronal MRIs of the patient's with spike dipoles (lower) are shown. Note the dramatic change in the involved sensors when MC was not employed, as indicated by the dotted circles on the top view, due to the movement of the patient's head.

(c) Temporal plot of head rotation to right side. The upper graph shown is a magnified view of a ~9 sec segment of the bottom multi-dimensional plot, blown up to correspond to the epoch shown in 2a. Before evolving into secondarily generalization, the patient's head turned about 14.2 degree to the right.

Note that the spike distribution seen in the upper panel of 2b, as well as the MEG spike dipole locations shown in the MRI slices, are discordant at a sublobar level; i.e. the spike sources are in the left middle frontal gyrus when MC was applied but move to the left superior frontal gyrus without MC application.