Figure 2. Effect of FTI on lamins is not specific to cell type or drug. (A) PreLB2 accumulates in FTI treated HeLa cells and HGPS dermal fibroblasts (HGADFN136). (B) The accumulation of preLB2 occurs with different FTIs, but not with a GGTI. Each FTI was used at 2.5 μM and GGTI-2147 was used at 10 μM. All samples were treated for 48 h. In all panels A–D, equal amounts of protein were loaded in each gel lane.