Table 5.
Estimated networks for the SCA1 and SCA3 phenotypes
| SCA1 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
PCNA |
1.0 |
. |
. |
. |
0.60 |
0.65 |
. |
−0.75 |
. |
−0.59 |
−0.59 |
. |
. |
|
TOP2A |
|
1.0 |
−0.64 |
. |
. |
. |
0.53 |
. |
. |
. |
. |
0.52 |
−0.48 |
|
MCM3 |
|
|
1.0 |
−0.43 |
. |
−0.41 |
. |
. |
0.66 |
. |
. |
0.88 |
−0.72 |
|
MCM6 |
|
|
|
1.0 |
. |
. |
−0.72 |
. |
0.64 |
. |
. |
0.49 |
−0.44 |
|
MCM2 |
|
|
|
|
1.0 |
. |
. |
. |
−0.46 |
0.55 |
. |
. |
. |
|
TK1 |
|
|
|
|
|
1.0 |
. |
0.66 |
0.47 |
0.50 |
. |
. |
. |
|
CDC6 |
|
|
|
|
|
|
1.0 |
0.58 |
. |
. |
. |
. |
. |
|
RFC4 |
|
|
|
|
|
|
|
1.0 |
. |
. |
−0.77 |
. |
. |
|
CDC45L |
|
|
|
|
|
|
|
|
1.0 |
. |
. |
−0.62 |
0.80 |
|
RFC3 |
|
|
|
|
|
|
|
|
|
1.0 |
. |
. |
. |
|
POLA2 |
|
|
|
|
|
|
|
|
|
|
1.0 |
0.61 |
−0.43 |
|
CDC7 |
|
|
|
|
|
|
|
|
|
|
|
1.0 |
0.77 |
|
RRM2 |
|
|
|
|
|
|
|
|
|
|
|
|
1.0 |
|
SCA3 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PCNA |
1.0 |
−0.52 |
. |
. |
0.37 |
0.42 |
0.64 |
. |
0.34 |
. |
. |
0.34 |
−0.44 |
|
TOP2A |
|
1.0 |
0.36 |
−0.49 |
0.37 |
. |
0.84 |
. |
0.62 |
0.35 |
. |
. |
−0.56 |
|
MCM3 |
|
|
1.0 |
. |
0.47 |
. |
. |
0.47. |
−0.40 |
−0.60 |
−0.40 |
. |
. |
|
MCM6 |
|
|
|
1.0 |
0.60 |
0.34 |
. |
−0.40 |
. |
0.37 |
. |
−0.43 |
. |
|
MCM2 |
|
|
|
|
1.0 |
−0.44 |
−0.43 |
. |
. |
. |
. |
0.45 |
. |
|
TK1 |
|
|
|
|
|
1.0 |
−0.35 |
. |
. |
. |
. |
. |
. |
|
CDC6 |
|
|
|
|
|
|
1.0 |
. |
−0.42 |
. |
0.39 |
. |
0.70 |
|
RFC4 |
|
|
|
|
|
|
|
1.0 |
0.34 |
0.82 |
0.49 |
−0.46 |
. |
|
CDC45L |
|
|
|
|
|
|
|
|
1.0 |
−0.37 |
. |
. |
0.60 |
|
RFC3 |
|
|
|
|
|
|
|
|
|
1.0 |
−0.58 |
0.34 |
. |
|
POLA2 |
|
|
|
|
|
|
|
|
|
|
1.0 |
0.46 |
. |
|
CDC7 |
|
|
|
|
|
|
|
|
|
|
|
1.0 |
. |
| RRM2 | 1.0 |
The estimated SCA1 and SCA3 Gaussian graphical model networks for the DNA synthesis and replication genes. Off-diagonal non-zero weights indicate the presence of an edge between two genes, ‘.’ denotes the lack of an edge, and ‘1.0’ is a visual placeholder.