Figure 3. A_2AR activity affected UUO-induced deposition of collagen III.

(A) Representative immunohistochemistry of Collagen III) (Col III) from the A_2AR KO and WT mice, at day 3, 7 and 14 post-UUO or Sham, following treatment of CGS21680 (CGS) or vehicle (Veh). Scale bar  = 50 µm, 400×. (B) Demonstration of Col III) deposition in the post-UUO WT animals received treatment of vehicle (WT+UUO+Veh) or A_2AR agonist CGS21680 (WT+UUO+CGS), and in the A_2AR post-UUO KO mice received treatment of vehicle (KO+UUO+Veh), or CGS21680 (KO+UUO+CGS), at day 3, 7 and 14 post-UUO, along with that in sham control animals (WT+Sham and KO+Sham)(n = 10 per group). Data are mean ± SD. * P<0.05 between two compared groups; NS, no significance.