Figure 4. A_2AR activity regulated UUO-induced expression of α-SMA and E-cadherin.

(A, B) Representative Western blot of α-SMA (A) and E-cadherin (B) in post-UUO kidneys. (C, D) Demonstration of the expression level of α-SMA and E-cadherin in the sham (WT+sham and KO+sham) control mice and animals subjected to UUO with CGS21680 treatment (WT+UUO+CGS and KO+UUO+CGS) or with vehicle treatment (WT+UUO+Veh and KO+UUO+Veh), at day 3, 7 and 14 post-UUO (n = 5 per group). Data are expressed as mean ± SD. *P<0.05 between the two groups. NS, no significance.