Figure 7. Dietary intervention is sufficient to reverse palmitate-induced caveolin-3 loss.

A) Western blots of cardiac tissue of mice maintained on standard, MCT, or palmitate diet for 12 weeks followed by 12 weeks of standard laboratory chow feeding. Caveolin-1 and -3 expression is normal. (Std standard, MCT medium chain triglyceride high fat control diet, P palmitate). B) Ex vivo contractile performance (RPP, pdP/dt and ndP/dt) and calcium sensitivity normalizes after 12 weeks of standard laboratory chow feeding. N = 6 (3 male and 3 female) per diet, linear regression analysis is not significant.