Table 6.
Trends on clinical outcomes, HRQoL and attitude toward treatment
| |
DAI total score Mean (SD) |
PANSS total score Mean (SD) |
GAF Mean (SD) |
CGI-S Mean (SD) |
EQ-VAS Mean (SD) |
EQ-utility Mean (SD) |
SF-36 PCS Mean (SD) |
SF-36 MCS Mean (SD) |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Non naïve | Naïve | Non naïve | Naïve | Non naïve | Naïve | Non naïve | Naïve | Non naïve | Naïve | Non naïve | Naïve | Non naïve | Naïve | Non naïve | Naïve | |
| Enrolment visit |
43.9 (5.0) |
41.0 (5.8) |
85.5 (27.2) |
98.2 (26.1) |
54.6 (13.9) |
49.9 (13.0) |
4.2 (1.1) |
4.6 (0.9) |
63.7 (18.0) |
63.3 (18.4) |
0.71 (0.3) |
0.68 (0.3) |
47.8 (9.2) |
48.3 (9.6) |
39.5 (9.6) |
37.1 (10.9) |
| Follow-up Examinatio2 |
43.9 |
41.7 |
79.8 |
81.1 |
57.1 |
58.6 |
4.1 |
3.9 |
66.2 |
67.8 |
0.74 |
0.76 |
48.2 |
48.7 |
40.6 |
39.8 |
| (5.0) |
(4.8) |
(27.4) |
(25.7) |
(13.7) |
(12.6) |
(1.1) |
(1.2) |
(16.8) |
(14.6) |
(0.3) |
(0.2) |
(9.5) |
(9.0) |
(9.3) |
(9.5) |
|
| Follow-up examination3 |
44.2 |
42.1 |
75.3 |
76.1 |
59.4 |
62.4 |
3.9 |
3.7 |
68.0 |
72.2 |
0.75 |
0.80 |
49.1 |
51.9 |
41.5 |
42.0 |
| (4.8) |
(5.1) |
(27.0) |
(24.5) |
(14.3) |
(12.0) |
(1.2) |
(1.1) |
(16.6) |
(14.4) |
(0.3) |
(0.2) |
(9.3) |
(8.1) |
(8.9) |
(8.0) |
|
| Follow-up examination4 |
44.2 |
42.6 |
71.4 |
66.9 |
61.4 |
67.6 |
3.8 |
3.4 |
70.5 |
75.5 |
0.79 |
0.81 |
49.7 |
53.5 |
41.9 |
43.0 |
| (4.8) |
(5.2) |
(25.8) |
(21.1) |
(14.2) |
(11.5) |
(1.2) |
(1.1) |
(16.6) |
(14.7) |
(0.2) |
(0.2) |
(8.9) |
(6.6) |
(8.9) |
(10.0) |
|
| Time effect* |
F(2.7,1254) = 2.7 P = 0.053 |
F(2.3,1752) = 156.9 P < 0.0001 |
F(2.4,1752) = 132.6 P < 0.0001 |
F(2.5,1752) = 68.9 P < 0.0001 |
F(2.7,1581) = 25.9 P < 0.0001 |
F(2.8,1569) = 10.9 P < 0.0001 |
F(2.8,1434) = 14.1 P < 0.0001 |
F(2.8,1434) = 17.1 P < 0.0001 |
||||||||
| Time effect between subgroups* | F(2.7,1254) = 1.1 P = 0.360 | F(2.3,1752) = 22.7 P < 0.0001 | F(2.4,1752) = 25.9 P < 0.0001 | F(2.5,1752) = 14.3 P < 0.0001 | F(2.7,1581) = 2.3 P = 0.080 | F(2.7,1569) = 1.6 P = 0.192 | F(2.8,1434) = 3.5 P = 0.017 | F(2.8,1434) = 3.0 P = 0.033 | ||||||||
*Time effect refers to the differences estimated between mean observations at any pair of examinations, during the observational period, on the full sample.
§ Time effect estimated comparing two subgroups: non naïve versus naïve patients.