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. 2013 Apr 9;8(4):e61509. doi: 10.1371/journal.pone.0061509

Figure 3. Synchronization modulation of TEP is mediated by the Na/K pump.

Figure 3

A. Ouabain at all concentrations applied significantly decreased resting TEP, which was measured immediately after SM. Time courses depicting stimulation with and without ouabain showed that ouabain in 1 µM to 1000 µM progressively depressed TEP increases. B. Stimulation without ouabain increased TEP by about 3.03 mV from pre-SM values. This increase was significantly inhibited by ouabain treatment for 1 hr, suggesting that depolarization is offset by decreased activity of the Na/K pump. Stimulation applied to cells incubated with 1 µM ouabain for>24 hrs elicited almost no response. * p<0.05, ** p<0.01, all comparing no ouabain control with ouabain treated monolayers (A: top line vs. all other lines, or B: second column vs. all other columns). N  =  4–6 for all data points.