Figure 5. Conductance gating models for the different current components used in our CG cell NEURON model.

Rate constants are k(0 mV) rate times the voltage dependence (e^a) which is raised to the E_M power (mV) to obtain the final rate. G_max and 0 current potentials are given for each conductance. For I_SA models, G_ISA(c) and G_ISA(r), the I₁−I₂ transition between closed inactivated states is generally not rate limiting, and thus effectively invisible, but was adjusted to preserve detailed balances. More complex models have been proposed for I_SA, but these models capture the basic gating properties of the I_SA channel over a wide range of voltages. For the TASK-3 channel, and the residual K_2P current in CG cells remaining after mDPP6 RNAi treatment, G_K2P, the model has 2 independent gates which must both be open to conduct. The linear leak component is always open and modeled to be Na⁺ selective to match the relatively high input resistance of CG cells while still producing the large change in E_rest between Control and mDPP6 RNAi CG cells.