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. Author manuscript; available in PMC: 2014 Feb 1.
Published in final edited form as: Bioorg Med Chem Lett. 2012 Dec 20;23(3):614–619. doi: 10.1016/j.bmcl.2012.12.030

Scheme 1.

Scheme 1

Synthesis of 7a–7ag, 7aj–7al.

Reagents and conditions: (i) 2 (1 equiv.), MOMCl (1.2 equiv.), DMAP (0.1 equiv.), DIPEA (1.4 equiv.) CH2Cl2, 0°C to rt, overnight, 85%; (ii) 3 (1 equiv.), 4-methoxyphenol (1.1 equiv.), NaH (1.1 equiv.), 1,4-dioxane, 15°C to rt, overnight, 65%; (iii) 4 (1 equiv.), BBr3 (1.1 equiv.), CH2Cl2, -78°C to rt, 1h, 93%; (iv) 5 (1 equiv.), 6a-6ag, 6aj-6al (1.2 equiv.), K2CO3 (1.5 equiv.), DMF, rt, overnigt, 40-95%.