Table 5.
Interventional studies in paediatric and neonatal patients
| Country(Setting) | Intervention | Duration | Sample | Outcome | Reference |
|---|---|---|---|---|---|
| Israel (Children Hospital, PCCD) | Pre/post implementation of CPOE and CDSS | 3 years | 13124 drug orders in first part 46970 orders in second part | 3 errors were identified in the first part of the study (all were overdoses); No errors were identified in the second part. | [56] |
| Israel (Children hospital, PICU) | CPOE implementation in four different periods | 3 years | 5000 PICU medication orders | 273 (5.5 %) medication orders contained prescription errors; 83 % of prescription errors were reduced after CDSS implemented. | [57] |
| Iran (Teaching hospital, Neonatal ward) | Comparison between physician order entry (POE) and nurse order entry (NOE) methods effect on reducing dosing MEs. | 4 months | 158 neonates | 80 % of non-intercepted medication errors in POE (period 1) occurred in the prescribing stage compared to 60 % during NOE (period 2); Prescribing errors were decreased from 10.3 % with POE to 4.6 % with NOE period, respectively. | [58] |
| Iran (Teaching hospital, Neonatal ward) | Comparison of CPOE effect without and with CDSS in three periods. | 7.5 months | 248 patients | MEs rates before intervention implemented (period 1) was 53 %; Implementation of CPOE without CDSS the MEs rate was 51 %; After CDSS was added the MEs rate was 34 %; Overdose was the most frequent type of errors. | [59] |
| Egypt (Teaching hospital, PICU) | Pre/post (physician education; new medication chart; physician feedback) study of prescribing errors in PICU. | 10 months | Pre :1417 medication orders, Post: 1096 medication orders | 1107 (78 %) orders had at least one prescribing error; Significant reduction in prescribing error rate to 35 % post-intervention (P < 0.001); Severe errors reduced from 29.7 % to 7 % after intervention. | [60] |
PCCD: Paediatric Clinical Care Department; CPOE: Computerized Physician Order Entry; CDSS: Clinical Decision Support System; PICU: Paediatric Intensive Care Unit.