Fig. 1.

Changes in miRNA expression after treatment with APDs. a–c Hierarchical clustering of significantly dysregulated miRNA microarray expression in APD-treated mouse brain (log transformed, median centered and uncentered correlation, average linkage clustering; Cluster 3.0) (Eisen et al. 1998). Blue low expression, yellow high expression. Images produced with Java TreeView (version 1.1.1) (Saldanha 2004). a Haloperidol and saline treatment groups. b Olanzapine and saline treatment groups. c Clozapine and saline treatment groups. d Microarray expression and qPCR expression of selected miRNA from olanzapine and haloperidol treatment groups. Bars represent fold change in expression + SEM (APD treated vs. saline)