Table 2. Serum E2 and T levels, and body and uterus weight in rats at the time of sacrifice.

	Female Sham rats	Female ovariectomized rats	Male Sham rats	Male orchidectomized rats
No. of animals (n)	8	8	8	8
Change in serum E2 level (ng/mL)	0.052±0.0034	0.036±0.0036 **	-	-
Change in serum T level (ng/mL)	-	-	2.625±0.445	0.238±0.0534***
Change in body weight (g)	11.09±2.211	34.24±2.286***	31.97±10.03	38.02±3.736
Uterus weight (mg)	0.1184±0.008	0.051±0.003***	-	-

Values are means±SEM. Differences between gonadectomized and sham-operated rats were assessed using Mann-Whitney test: **p<0.001; ***p<0.0001.