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. 2013 Apr 9;8(4):e61057. doi: 10.1371/journal.pone.0061057

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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Percent collagen fraction area (mean+SEM) measured by picrosirius staining of the left ventricle increased 12–15 weeks after weekly i.p. injections of low dose LPS (0.5±0.1 mg/kg, n = 15) or moderate dose LPS (12±1 mg/kg, n = 15) compared with saline (control, n = 17) (P<0.001, one way ANOVA). There was a greater increase with moderate dose LPS than with low dose LPS (P<0.05).