Table 3.
Upregulated genes associated with the Kyoto Encyclopedia of Genes and Genomes (KEGG) biochemical pathways (p < 0.05) in the prefrontal cortex of high analgesia (HA) mice
| KEGG biochemical pathway | Number of genes | EASE score | Genes |
|---|---|---|---|
| Long-term potentiation | 6 | 0.000 | MAPK1, ATF4, PPP3CA, PPP1CB, PRKCC, 1500003O03RIK |
| Natural killer cell-mediated cytotoxicity | 6 | 0.001 | MAPK1, H2-T23, PPP3CA, PAK1, PRKCC, 1500003O03RIK |
| MAPK signaling pathway | 8 | 0.001 | MAPK1, ATF4, RASGRP1, CACNG3, PPP3CA, PAK1, PRKCC, 1500003O03RIK |
| Focal adhesion | 7 | 0.001 | MAPK1, CAV2, ITGAV, PAK1, CAPN2, PPP1CB, PRKCC |
| VEGF signaling pathway | 5 | 0.001 | MAPK1, CASP9, PPP3CA, PRKCC, 1500003O03RIK |
| T cell receptor signaling pathway | 5 | 0.004 | MAPK1, RASGRP1, PPP3CA, PAK1, 1500003O03RIK |
| Apoptosis | 4 | 0.014 | CASP9, PPP3CA, CAPN2, 1500003O03RIK |
| Alzheimer's disease | 5 | 0.015 | MAPK1, CASP9, PPP3CA, CAPN2, 1500003O03RIK |
| Fc gamma R-mediated phagocytosis | 4 | 0.017 | MAPK1, PAK1, ARPC5, PRKCC |
| Regulation of actin cytoskeleton | 5 | 0.036 | MAPK1, ITGAV, PAK1, ARPC5, PPP1CB |
| Axon guidance | 4 | 0.038 | MAPK1, PPP3CA, PAK1, 1500003O03RIK |
| Amyotrophic lateral sclerosis (ALS) | 3 | 0.042 | CASP9, PPP3CA, 1500003O03RIK |