Table 8.
Clusters of genes determined by the DAVID v6.7 software (p < 0.05) affected by chronic mild stress (CMS) in the prefrontal cortex of high analgesia (HA) mice
| Gene symboal | Gene name | Expression | Fold Change |
|---|---|---|---|
| Regulation of cell communication/regulation of signal transduction | |||
| Bat2 | HLA-B-associated transcript 2 | ↑ | 1.48 |
| Acvr1c | Activin A receptor, type IC | ↓ | −2.10 |
| Bai1 | Brain-specific angiogenesis inhibitor 1 | ↑ | 1.61 |
| Dkk3 | Dickkopf homolog 3 (Xenopus laevis) | ↓ | −1.48 |
| Drd1a | Dopamine receptor D1A | ↓ | −1.28 |
| Mtap1b | Microtubule-associated protein 1B | ↓ | −1.45 |
| Palm | Paralemmin | ↑ | 1.34 |
| Cbx3 | Predicted gene 6917; similar to chromobox homolog 3 | ↓ | −2.17 |
| Rgs9 | Regulator of G-protein signaling 9 | ↓ | −2.35 |
| Sostdc1 | Sclerostin domain containing 1 | ↑ | 1.50 |
| Srp9 | Signal recognition particle 9 | ↑ | 2.49 |
| Timp2 | Tissue inhibitor of metalloproteinase 2 | ↑ | 1.55 |
| Regulation of hormone secretion/regulation of insulin secretion | |||
| Bat2 | HLA-B-associated transcript 2 | ↑ | 1.48 |
| Acvr1c | Activin A receptor, type IC | ↓ | −2.10 |
| Avp | Arginine vasopressin | ↑ | 3.67 |
| Drd1a | Dopamine receptor D1A | ↓ | −1.28 |
| Il12a | Interleukin 12a | ↓ | −1.32 |
| Kl | Klotho | ↓ | −2.20 |
| Nnat | Neuronatin | ↑ | 1.50 |
| Pfkm | Phosphofructokinase, muscle | ↓ | −1.83 |
| Ion binding | |||
| Arl3 | ADP-ribosylation factor-like 3 | ↑ | 3.10 |
| Lasp1 | LIM and SH3 protein 1 | ↓ | −1.85 |
| Nell2 | NEL-like 2 (chicken) | ↑ | 1.70 |
| Acvr1c | Activin A receptor, type IC | ↓ | −2.10 |
| Calb2 | Calbindin 2 | ↑ | 1.69 |
| Cacna2d1 | Calcium channel, voltage-dependent, alpha2/delta subunit 1 | ↓ | −1.38 |
| Calml4 | Calmodulin-like 4 | ↑ | 1.52 |
| Clic6 | Chloride intracellular channel 6 | ↑ | 1.77 |
| Dgkg | Diacylglycerol kinase, gamma | ↑ | 1.30 |
| Hpcal4 | Hippocalcin-like 4 | ↑ | 1.22 |
| Kl | Klotho | ↑ | 1.92 |
| Mmp17 | Matrix metallopeptidase 17 | ↓ | −1.26 |
| Myl4 | Myosin, light polypeptide 4 | ↓ | −1.50 |
| Pfkm | Phosphofructokinase, muscle | ↓ | −1.83 |
| Kcnb1 | Potassium voltage gated channel, Shab-related subfamily | ↓ | −1.98 |
| Kcnh1 | Potassium voltage-gated channel, subfamily H (eag-related) | ↓ | −1.85 |
| Pnck | Pregnancy upregulated non-ubiquitously expressed CaM kinase | ↑ | 1.40 |
| Prkcb | Protein kinase C, beta | ↓ | −0.65 |
| Sparc | Secreted acidic cysteine rich glycoprotein | ↑ | 1.54 |
| Slc17a7 | Solute carrier family 17 | ↑ | 1.22 |
| Zfp423 | Zinc finger protein 423; similar to mKIAA0760 protein | ↑ | 1.42 |
| Zcchc12 | Zinc finger, CCHC domain containing 12 | ↑ | 1.89 |
| Regulation of primary metabolic process/regulation of cAMP biosynthetic process | |||
| Avp | Arginine vasopressin | ↑ | 3.67 |
| Drd1a | Dopamine receptor D1A | ↓ | −1.28 |
| Palm | Paralemmin | ↑ | 1.34 |
| Kcnh1 | Potassium voltage-gated channel, subfamily H | ↓ | −1.85 |
| Cbx3 | Predicted gene 6917; similar to chromobox homolog 3 | ↓ | −2.17 |
| Rbbp4 | Retinoblastoma binding protein 4 | ↓ | −1.87 |
| Srp9 | Signal recognition particle 9 | ↑ | 2.49 |
| Timp2 | Tissue inhibitor of metalloproteinase 2 | ↑ | 1.55 |
| Zfp423 | Zinc finger protein 423; similar to mKIAA0760 protein | ↑ | 1.42 |
| Zcchc12 | Zinc finger, CCHC domain containing 12 | ↑ | 1.89 |
| Cell junction/adherens junction | |||
| Lasp1 | LIM and SH3 protein 1 | ↓ | −1.85 |
| Calb2 | Calbindin 2 | ↑ | 1.69 |
| Cbln1 | Cerebellin 1 precursor protein; similar to precerebellin-1 | ↓ | −2.06 |
| Pak1 | p21 protein (Cdc42/Rac)-activated kinase 1 | ↓ | −2.06 |
| Pkp2 | Plakophilin 2 | ↑ | 1.26 |
| Slc17a7 | Solute carrier family 17 | ↑ | 1.22 |
| Response to endogenous stimulus/response to hormone stimulus | |||
| Bat2 | HLA-B-associated transcript 2 | ↑ | 1.48 |
| Bat5 | HLA-B-associated transcript 5 | ↑ | 3.36 |
| Rasd2 | RASD family, member 2 | ↓ | −1.73 |
| Acvr1c | Activin A receptor, type IC | ↓ | −2.10 |
| Avp | Arginine vasopressin | ↑ | 3.67 |
| Drd1a | Dopamine receptor D1A | ↓ | −1.28 |
| H2-L | Histocompatibility 2, D region; histocompatibility 2 | ↑ | 2.56 |
| Il12a | Interleukin 12a | ↓ | −1.32 |
| Nnat | Neuronatin | ↑ | 1.50 |
| Ppp1r1b | Protein phosphatase 1, regulatory (inhibitor) subunit 1B | ↓ | −1.68 |
| Ptpra | Protein tyrosine phosphatase, receptor type, A | ↓ | −1.78 |
| Rgs9 | Regulator of G-protein signaling 9 | ↓ | −2.35 |
| Slc17a7 | Solute carrier family 17 | ↑ | 1.22 |
| Trh | Thyrotropin-releasing hormone | ↑ | 1.91 |
| Homeostatic process/regulation of biological quality | |||
| Avp | Arginine vasopressin | ↑ | 3.67 |
| Drd1a | Dopamine receptor D1A | ↓ | −1.28 |
| Nts | Neurotensin | ↑ | 1.58 |
| Palm | Paralemmin | ↑ | 1.34 |
| Pfkm | Phosphofructokinase, muscle | ↓ | −1.83 |
| Prkcb | Protein kinase C, beta | ↓ | −0.65 |
| Ppp1r1b | Protein phosphatase 1, regulatory (inhibitor) subunit 1B | ↓ | −1.68 |
| Slc17a7 | Solute carrier family 17 | ↑ | 1.22 |
| Generation of neurons/neurogenesis/neuron differentiation | |||
| Acvr1c | Activin A receptor, type IC | ↓ | −2.10 |
| Dkk3 | Dickkopf homolog 3 (Xenopus laevis) | ↓ | −1.48 |
| Drd1a | Dopamine receptor D1A | ↓ | −1.28 |
| Kl | Klotho | ↑ | 1.92 |
| Mtap1b | Microtubule-associated protein 1B | ↓ | −1.45 |
| Nnat | Neuronatin | ↑ | 1.50 |
| Pak1 | p21 protein (Cdc42/Rac)-activated kinase 1 | ↓ | −2.06 |
| Pigt | Phosphatidylinositol glycan anchor biosynthesis, class T | ↓ | −3.22 |
| Pkp2 | Plakophilin 2 | ↑ | 1.26 |
| Prlr | Prolactin receptor | ↑ | 1.62 |
| Sostdc1 | Sclerostin domain containing 1 | ↑ | 1.50 |
| Timp2 | Tissue inhibitor of metalloproteinase 2 | ↑ | 1.55 |
| Zfp423 | Zinc finger protein 423; similar to mKIAA0760 protein | ↑ | 1.42 |
| Apoptosis/cell death | |||
| Bat2 | HLA-B-associated transcript 2 | ↑ | 1.48 |
| Acvr1c | Activin A receptor, type IC | ↓ | −2.10 |
| Pigt | Phosphatidylinositol glycan anchor biosynthesis, class T | ↓ | −3.22 |
| Regulation of gene expression/regulation of transcription | |||
| Kcnh1 | Potassium voltage-gated channel, subfamily H | ↓ | −1.85 |
| Cbx3 | Predicted gene 6917; similar to chromobox homolog 3 | ↓ | −2.17 |
| Rbbp4 | Retinoblastoma binding protein 4 | ↓ | −1.87 |
| Srp9 | Signal recognition particle 9 | ↑ | 2.49 |
| Zfp423 | Zinc finger protein 423; similar to mKIAA0760 protein | ↑ | 1.42 |
| Zcchc12 | Zinc finger, CCHC domain containing 12 | ↑ | 1.89 |
| Signal transducer activity/receptor activity | |||
| Acvr1c | Activin A receptor, type IC | ↓ | −2.10 |
| Bai1 | Brain-specific angiogenesis inhibitor 1 | ↑ | 1.61 |
| Drd1a | Dopamine receptor D1A | ↓ | −1.28 |
| Folr1 | Folate receptor 1 (adult) | ↑ | 1.23 |
| Igsf1 | Immunoglobulin superfamily, member 1 | ↑ | 2.09 |
| Kcnh1 | Potassium voltage-gated channel, subfamily H | ↓ | −1.85 |
| Tomm22 | Predicted gene 12906; predicted gene 7250 | ↑ | 2.75 |
| Prlr | Prolactin receptor | ↑ | 1.62 |
| Ptpra | Protein tyrosine phosphatase, receptor type, A | ↓ | −1.78 |
| Rgs9 | Regulator of G-protein signaling 9 | ↓ | −2.35 |
“↑” upregulation, “↓” downregulation