Table 9.
Clusters of genes determined by the DAVID v6.7 software (p < 0.05) affected by chronic mild stress (CMS) in the prefrontal cortex of low analgesia (LA) mice
| Gene symbol | Gene name | Expression | Fold change |
|---|---|---|---|
| Signal transduction | |||
| Fcer1g | Fc receptor, IgE, high affinity I, gamma polypeptide | ↓ | −2.66 |
| Gpr88 | G-protein coupled receptor 88 | ↓ | −1.23 |
| Rab5b | RAB5B, member RAS oncogene family | ↑ | 2.36 |
| Rasgrp1 | RAS guanyl-releasing protein 1 | ↑ | 1.31 |
| Rasd2 | RASD family, member 2 | ↓ | −1.64 |
| Cntnap4 | Contactin-associated protein-like 4 | ↑ | 0.75 |
| Crhr1 | Corticotropin-releasing hormone receptor 1 | ↓ | −1.76 |
| Dgke | Diacylglycerol kinase, epsilon | ↑ | 1.66 |
| Dgkg | Diacylglycerol kinase, gamma | ↑ | 1.25 |
| Grm5 | Glutamate receptor, metabotropic 5 | ↓ | −0.95 |
| Gdi1 | Guanosine diphosphate (GDP) dissociation inhibitor 1 | ↑ | 1.99 |
| Matk | Megakaryocyte-associated tyrosine kinase | ↓ | −1.53 |
| Prkcc | Protein kinase C, gamma | ↑ | 2.54 |
| Rgs9 | Regulator of G-protein signaling 9 | ↓ | −2.31 |
| Spock2 | Sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2 | ↑ | 1.44 |
| Response to stress | |||
| Fcer1g | Fc receptor, IgE, high affinity I, gamma polypeptide | ↓ | −2.66 |
| Rasd2 | RASD family, member 2 | ↓ | −1.64 |
| S100a8 | S100 calcium binding protein A8 (calgranulin A) | ↓ | −3.78 |
| S100a9 | S100 calcium binding protein A9 (calgranulin B) | ↓ | −3.32 |
| Capn2 | Calpain 2 | ↑ | 3.76 |
| Camp | Cathelicidin antimicrobial peptide | ↓ | −1.72 |
| Crhr1 | Corticotrophin-releasing hormone receptor 1 | ↓ | −1.76 |
| Grm5 | Glutamate receptor, metabotropic 5 | ↓ | −0.95 |
| Mt3 | Metallothionein 3 | ↑ | 1.89 |
| Mpo | Myeloperoxidase | ↓ | −1.85 |
| Nnat | Neuronatin | ↑ | 1.83 |
| Igh-VJ558 | Predicted gene 5353; immunoglobulin heavy chain (J558 family) | ↓ | −1.63 |
| Prkcc | Protein kinase C, gamma | ↑ | 2.54 |
| Rgs9 | Regulator of G-protein signaling 9 | ↓ | −2.31 |
| Dendrite/neuron projection | |||
| Crmp1 | Collapsin response mediator protein 1 | ↑ | 1.36 |
| Cntnap4 | Contactin-associated protein-like 4 | ↑ | 0.75 |
| Prkcc | Protein kinase C, gamma | ↑ | 2.54 |
| Immune effector process/immune response | |||
| Atp6v0a1 | ATPase, H + transporting, lysosomal V0 subunit A1 | ↑ | 1.62 |
| Fcer1g | Fc receptor, IgE, high affinity I, gamma polypeptide | ↓ | −2.66 |
| S100a9 | S100 calcium binding protein A9 (calgranulin B) | ↓ | −3.32 |
| Mpo | Myeloperoxidase | ↓ | −1.85 |
| Igh-VJ558 | Predicted gene 5353; immunoglobulin heavy chain (J558 family) | ↓ | −1.63 |
| Intracellular signaling cascade/GTPase regulator activity | |||
| Rab5b | RAB5B, member RAS oncogene family | ↑ | 2.36 |
| Rasgrp1 | RAS guanyl-releasing protein 1 | ↑ | 1.31 |
| Rasd2 | RASD family, member 2 | ↓ | −1.64 |
| Dgke | Diacylglycerol kinase, epsilon | ↑ | 1.66 |
| Dgkg | Diacylglycerol kinase, gamma | ↑ | 1.25 |
| Gdi1 | Guanosine diphosphate (GDP) dissociation inhibitor 1 | ↑ | 1.99 |
| Prkcc | Protein kinase C, gamma | ↑ | 2.54 |
| Rgs9 | Regulator of G-protein signaling 9 | ↓ | −2.31 |
| Behavior/response to external stimulus | |||
| Fcer1g | Fc receptor, IgE, high affinity I, gamma polypeptide | ↓ | −2.66 |
| Rasd2 | RASD family, member 2 | ↓ | −1.64 |
| S100a8 | S100 calcium binding protein A8 (calgranulin A) | ↓ | −3.78 |
| S100a9 | S100 calcium binding protein A9 (calgranulin B) | ↓ | −3.32 |
| Crhr1 | Corticotrophin-releasing hormone receptor 1 | ↓ | −1.76 |
| Grm5 | Glutamate receptor, metabotropic 5 | ↓ | −0.95 |
| Prkcc | Protein kinase C, gamma | ↑ | 2.54 |
| Ion homeostasis/regulation of biological quality | |||
| Crym | Crystallin, mu | ↑ | 1.85 |
| Grm5 | Glutamate receptor, metabotropic 5 | ↓ | −0.95 |
| Ltf | Lactotransferrin | ↓ | −2.59 |
| Mt3 | Metallothionein 3 | ↑ | 1.89 |
| Sepw1 | Selenoprotein W, muscle 1 | ↑ | 1.39 |
| Slc26a4 | Solute carrier family 26, member 4 | ↑ | 1.32 |
| Nervous system development/cell differentiation | |||
| Atp6v0a1 | ATPase, H + transporting, lysosomal V0 subunit A1 | ↑ | 1.62 |
| Capn2 | Calpain 2 | ↑ | 3.76 |
| Grm5 | Glutamate receptor, metabotropic 5 | ↓ | −0.95 |
| Kif3a | Kinesin family member 3A | ↓ | −1.97 |
| Lbh | Limb-bud and heart | ↑ | 1.50 |
| Mt3 | Metallothionein 3 | ↑ | 1.89 |
| Mog | Myelin oligodendrocyte glycoprotein | ↑ | 1.37 |
| Nnat | Neuronatin | ↑ | 1.83 |
| Nfib | Nuclear factor I/B | ↑ | 1.37 |
| Pigt | Phosphatidylinositol glycan anchor biosynthesis, class T | ↓ | −1.25 |
| Prkcc | Protein kinase C, gamma | ↑ | 2.54 |
| Rgs9 | Regulator of G-protein signaling 9 | ↓ | −2.31 |
| Slc26a4 | Solute carrier family 26, member 4 | ↑ | 1.32 |
| Thra | Thyroid hormone receptor alpha; similar to thyroid hormone receptor | ↑ | 1.31 |
| Regulation of apoptosis/regulation of programmed cell death | |||
| Fcer1g | Fc receptor, IgE, high affinity I, gamma polypeptide | ↓ | −2.66 |
| Eef1a2 | Eukaryotic translation elongation factor 1 alpha 2 | ↑ | 1.90 |
| Mal | Myelin and lymphocyte protein, T-cell differentiation protein | ↑ | 1.37 |
| Regulation of transcription/regulation of gene expression | |||
| Atp6v0a1 | ATPase, H + transporting, lysosomal V0 subunit A1 | ↑ | 1.62 |
| Atf4 | Activating transcription factor 4 | ↑ | 1.45 |
| Brms1l | Breast cancer metastasis-suppressor 1-like | ↑ | 1.33 |
| Eef1a2 | Eukaryotic translation elongation factor 1 alpha 2 | ↑ | 1.90 |
| Lbh | Limb-bud and heart | ↑ | 1.50 |
| Nfib | Nuclear factor I/B | ↑ | 1.37 |
| Thra | Thyroid hormone receptor alpha; similar to thyroid hormone receptor | ↑ | 1.31 |
| Zfp238 | Zinc finger protein 238 | ↑ | 1.81 |
| Signal transducer activity/receptor activity/G-protein coupled receptor activity | |||
| Fcer1g | Fc receptor, IgE, high affinity I, gamma polypeptide | ↓ | −2.66 |
| Gpr88 | G-protein coupled receptor 88 | ↓ | −1.23 |
| Crhr1 | Corticotrophin-releasing hormone receptor 1 | ↓ | −1.76 |
| Grm5 | Glutamate receptor, metabotropic 5 | ↓ | −0.95 |
| Mog | Myelin oligodendrocyte glycoprotein | ↑ | 1.37 |
| Tomm22 | Predicted gene 12906; predicted gene 7250 | ↓ | −2.18 |
| Rgs9 | Regulator of G-protein signaling 9 | ↓ | −2.31 |
| Thra | Thyroid hormone receptor alpha; similar to thyroid hormone receptor | ↑ | 1.31 |
| Cognition | |||
| Grm5 | Glutamate receptor, metabotropic 5 | ↓ | −0.95 |
| Prkcc | Protein kinase C, gamma | ↑ | 2.54 |
| Rgs9 | Regulator of G-protein signaling 9 | ↓ | −2.31 |
“↑” upregulation, “↓” downregulation