Table II. Outcomes of Interest.
Patient | Day of engraftment |
Day platelet transfusion independent |
Mucositis | CD 3 Chimerism | Acute GVHD? |
Treatment for acute GVHD |
Chronic GVHD? |
Treatment for chronic GVHD |
Karnofsky score at last follow-up |
Last follow-up |
Additional comments |
||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 mo | 6 mo | 12 mo | |||||||||||
1 | +15 | N/E | Grade 3b | 100%/ 100% (CD33) | N/E | N/E | No | N/A | N/A | N/A | N/E | Day +37 | Patient died at day +37 from disseminated toxoplasmosis and CMV; no GVHD was seen on autopsy |
2 | +16 | +25 | Grade 3b | 100%/100%(CD33) | 100% | 100% | Yes Grade II (gut) | Cyclosporine continued. Added Beclomethasone | No | N/A | 100% | 3 yrs | Doing well, transfusion independent, no secondary malignancies |
3 | +14 | +29 | Grade 2 | 100%/100%(CD33) | 100% | 100% | Yes Grade III (skin, gut, liver) | Cyclosporine continued. Added Prednisone Basiliximab | Yes, extensive (oral and pulmonary) | Cyclosporine continued, Prednisone, Oral MMF | 90% | 2 yrs | Doing well with active chronic GVHD of oral mucosa, transfusion independent, no secondary malignancies |