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. Author manuscript; available in PMC: 2013 Apr 10.
Published in final edited form as: Eur J Neurosci. 2012 Jan;35(2):300–308. doi: 10.1111/j.1460-9568.2011.07956.x

Fig. 2.

Fig. 2

RCS knockout (KO) mice display increased anxiety-like behavior in the open field and elevated plus maze. (A) RCS KO mice spent less time in the center region of the open field compared with wild-type (WT) mice (WT = 31.0 s, KO = 18.8 s, F1,42 = 13.7751, P = 0.0006). (B) There was no difference between WT and KO mice in distance traveled in this test (WT = 2713.2 cm, KO = 2690.2 cm, F1,42 = 0.8639, P = 0.64). (C) RCS KO mice entered open arms significantly less often than their WT counterparts (WT = 33.47% open/total entries, KO = 22.89% open/total entries, F1,42 = 11.2173, P = 0.001727). Similarly, RCS KO mice entered open arms for significantly less time than WT mice (WT = 21.39% open/total time, KO = 11.73% open/total time, F1,42 = 12.7998, P = 0.0089). (D) RCS KO and WT mice had no difference in mean number of total arm entries (F1,42 = 0.4133, P = 0.6828). Total n for all tasks (WT = 24, KO = 20).