Figure 4. The full giant component of the drug-target protein network.

Drugs (hexagons) belonging to the DS are indicated in red. The interactions between DS drugs and target proteins (circles) are denoted by wavy red arrows. Each node is colored based on the disorder class to which the disease-gene product belongs. The class of a disease gene is assigned if all the related diseases to the gene are of the same class. Otherwise, it is assigned Grey class. Disorders having distinct multiple clinical features are assigned to the multiple class. When there was insufficient information available for a clear assignment, it was annotated as unclassified class. When a gene is not directly implicated in any disorder it was annotated as NA (not assigned) class. The rest of legends are self-explanatory (see also Ref. 32).