Figure 6. Ebf2 promotes the binding of Pparγ to its brown fat-selective gene targets.
(A) ChIP-qPCR analysis of Pparγ binding in adipocytes from Pparγ-deficient cells that were first transduced with Pparγ retrovirus, followed by transduction with either a control (ctl) or Ebf2-expressing retrovirus. (B) ChIP-qPCR analysis of Pparγ binding in Scrambled (Ctl) or Si-Ebf2 treated brown adipocytes. (C) ChIP-qPCR analysis of Pparγ binding in mature adipocytes from control (Ctl) and Ebf2-expressing white preadipocytes. All data are normalized to background binding (at non-specific Insulin and 18s rRNA loci) and presented as mean ± SD, n > 3.