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. Author manuscript; available in PMC: 2014 May 1.
Published in final edited form as: Crit Rev Oncol Hematol. 2012 Dec 23;86(2):97–103. doi: 10.1016/j.critrevonc.2012.11.008

Fig. 3. Representation of biologic activity of KDM3B, KDM5A and KDM6A.

Fig. 3

KDM3B is responsible for transcriptional activation of tumor suppressor genes through the H3K9me2/1 demethylation. KDM5A/PcG complex can cooperate to induce the silencing of oncogenes. KDM5A interacts directly with RBP-J and modulates Myc activity resulting in a tumor suppressor effect. PcG genes through the H3K27 trimethylation lead to oncogene silencing. KDM6A acts antagonistically to PcG, promoting oncogene activation.