Mir-21 increases VEGF and IL-6 expression following P2X7R signaling. Mir-21 expression levels in (A) normal, non-lesional, and lesional psoriatic skin and in (B) normal human skin 12 h following injections with BzATP, KN-62, BzATP + KN-62, or PBS control (No Tx). Mir-21 expression levels were normalized to non-treated normal human skin. Bars represent the mean ± SD of triplicates. Asterisk indicates a significant difference compared to non-treated normal skin, p < 0.05. (C) VEGF and IL-6 present in cutaneous lysates 72 h following injections with PBS, BzATP, PBS + mir-21 Atg, or BzATP + mir-21 Atg. Bars represent the mean ± SD of replicates. Asterisk indicates significant difference between indicated groups. Representative of three independent experiments.