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. Author manuscript; available in PMC: 2014 Mar 1.
Published in final edited form as: Vaccine. 2013 Jan 23;31(11):1480–1489. doi: 10.1016/j.vaccine.2013.01.012

Figure 4. Nasal immunization with rPA formulated with non-toxin adjuvants induces antigen-specific mucosal IgA and IgG.

Figure 4

Mice were immunized as described in Figure 1. The data represents one experiment in C3H/HeN mice and one experiment in C57BL/6 mice (4 – 5 mice per group). Day 42 fecal (A), vaginal (B) and nasal wash (C) samples were collected and tested for the presence of anti-rPA IgG and IgA by ELISA to determine anti-rPA IgA and IgG log2 endpoint titers. Bars represent mean ± standard deviation. Statistical analysis was performed using one-way ANOVA and Tukey’s multiple comparison test. The numbers above the error bars indicate which groups (1-9) are significantly different from the indicated group. Samples that had no detectable anti-rPA IgG or IgA titers were assigned a log2 value of one less than the starting log2 dilution for statistical analysis.