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. Author manuscript; available in PMC: 2013 Apr 10.
Published in final edited form as: Stroke. 2012 Feb 23;43(4):980–986. doi: 10.1161/STROKEAHA.111.632075

Table 3.

Association Results of the 11 MI/CAD Risk Loci and Risk Scores With Ischemic Stroke, by TOAST Subtypes

SNP Cardioembolic (n=1216)
 Large-Artery (n=1137)
 Small-Vessel (n=1043)
 Other Known Causes (n=324)
 Undetermined Causes (n=2087)
OR (95% CI)* P OR (95% CI)* P OR (95% CI)* P OR (95% CI)* P OR (95% CI)* P
rs11206510 1.02 (0.89, 1.18) 0.78 0.91 (0.80, 1.04) 0.17 1.05 (0.91, 1.21) 0.50 0.89 (0.72, 1.11) 0.32 0.86 (0.76, 0.99) 0.03
rs646776 0.93 (0.83, 1.05) 0.25 0.91 (0.81, 1.03) 0.12 0.95 (0.84, 1.07) 0.38 1.01 (0.78, 1.31) 0.94 0.93 (0.82, 1.05) 0.24
rs17465637 1.01 (0.89, 1.16) 0.86 0.98 (0.87, 1.09) 0.69 1.12 (1.00, 1.26) 0.05 0.96 (0.79, 1.17) 0.69 1.01 (0.92, 1.10) 0.90
rs6725887 0.98 (0.83, 1.16) 0.84 1.01 (0.85, 1.19) 0.93 0.91 (0.76, 1.09) 0.30 1.45 (0.93, 2.26) 0.10 0.96 (0.83, 1.11) 0.58
rs9818870 1.17 (1.02, 1.35) 0.03 0.97 (0.83, 1.13) 0.66 0.91 (0.77, 1.07) 0.24 1.32 (0.92, 1.89) 0.13 0.99 (0.87, 1.12) 0.90
rs12526453 1.06 (0.95, 1.18) 0.31 0.93 (0.83, 1.03) 0.15 0.90 (0.80, 1.02) 0.09 1.03 (0.85, 1.25) 0.74 1.00 (0.91, 1.09) 0.99
rs4977574 1.02 (0.89, 1.17) 0.82 1.09 (0.99, 1.20) 0.09 1.03 (0.94, 1.14) 0.52 0.91 (0.69, 1.18) 0.47 1.01 (0.94, 1.09) 0.72
rs1746048 0.99 (0.88, 1.12) 0.93 1.05 (0.92, 1.2) 0.44 1.01 (0.86, 1.18) 0.94 0.97 (0.70, 1.33) 0.85 1.00 (0.91, 1.1) 0.96
rs3184504 1.05 (0.91, 1.22) 0.51 1.16 (0.96, 1.39) 0.11 1.03 (0.89, 1.20) 0.68 1.33 (1.02, 1.72) 0.04 1.12 (0.98, 1.27) 0.11
rs1122608 0.98 (0.88, 1.09) 0.67 1.06 (0.95, 1.18) 0.33 1.03 (0.92, 1.15) 0.66 1.03 (0.85, 1.26) 0.75 0.99 (0.91, 1.07) 0.74
rs9982601 1.05 (0.89, 1.25) 0.55 1.04 (0.89, 1.22) 0.63 1.06 (0.88, 1.27) 0.55 1.15 (0.83, 1.60) 0.39 1.02 (0.85, 1.22) 0.85
score 1 1.02 (0.98, 1.07) 0.29 1.02 (0.97, 1.06) 0.47 1.01 (0.95, 1.07) 0.85 1.06 (0.98, 1.14) 0.16 1.00 (0.96, 1.04) 0.97
score 2 1.04 (0.99, 1.08) 0.11 1.01 (0.96, 1.08) 0.63 1.00 (0.94, 1.07) 0.91 1.08 (1.01, 1.17) 0.03 1.00 (0.96, 1.05) 0.92

MI indicates myocardial infarction; CAD, coronary artery disease; TOAST, Trial of Org 10172 in Acute Stroke Treatment; SNP, single-nucleotide polymorphism; OR, odds ratio; CI, confidence interval; P, probability value.

*

ORs reflect the effect of the MI-associated risk allele with the previously published MI nonrisk allele as the reference allele defined in Table 1.