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. Author manuscript; available in PMC: 2014 Feb 1.
Published in final edited form as: Lancet Neurol. 2013 Feb;12(2):207–216. doi: 10.1016/S1474-4422(12)70291-0

Figure 2. Temporal ordering of CSF biomarkers.

Figure 2

Mean baseline levels of CSFAβ42 (A), P-tau (B), and t-tau (C) stratified into patients with MCI who developed AD dementia within 0 to 2.5 years (n=28), 2.5 to 5 years (n=32), and 5 to 10 years (n=12). Biomarker levels in a cognitively healthy control group are also given. Levels of Aβ42 did not differ among any of the MCI-AD groups with different intervals to AD dementia. Levels of t-tau and P-tau were significantly lower in late converters (5–10 years) compared with very early converters (0–2.5 years). Error bars represent the SEM. Reproduced with permission from Buchhave et al 26.