Table 4.
Frequency of mixed pathologies in autopsy series of elderly subjects.
| Pathologies (%)* | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Author | N | AD lesions | AD alone | AD + CVL | AD + LBD | VaD | DLB | FTD | Others |
| Galasko et al., 1994 | 170 (d) | 56.5 | 7.1 | – | 2.4 | 22.4 | 11.8 | ||
| Victoroff et al., 1995 | 196 (d) | 44.9 | 12.8 | – | 4.6 | 6.6 | 31.3 | ||
| Jellinger, 1996 | 540 (d) | 65.0 | 4.1 | – | 8.5 | 6.1 | 2.8 | 13.5 | |
| Nolan et al., 1998 | 87 (d) | 100 | 50 | 34 | – | – | |||
| Lim et al., 1999 | ? | ? | 36 | 45 | 22 | – | |||
| NUN study Riley et al., 2002 | 57 | 73/93 | – | – | |||||
| Akatsu et al., 2002 | 158 (d) | 46.2 | 5.7 | 21.5 | 17.7 | 3.2 | 5.7 | ||
| 382 (d) | 41.6 | 11.3 | 3.1 | 22.0 | 4.7 | 17.3 | |||
| 202 (d) | 63.9 | 9.5 | 5.9 | 11.9 | 4.6 | 11.9 | |||
| HAAS study Petrovitch et al., 2005 | 333 (235 d, 98 contr.) | <60 | 20 | 45 | – | 24 | |||
| MRC-CFAS (UK) Fernando and Ince, 2004 | 209 (48% d) | 70 | 21 | – | – | 78 | |||
| Andin et al., 2005 | 175 (clin. VaD) | – | 72 | – | 28 | ||||
| Jellinger, 2009b (retrospective) | 1700 (d) | 79.5 | 44.8 | 25.3 | 9.0 | 13.3 | |||
| Jellinger, 2009b (prospective) | 180 (d) | 82.7 | 48.8 | 23.9 | 10.0 | 7.8 | |||
| Nitrini et al., submitted | 110 (d) | 43.6 | 28.1 | 15.5 | (9.9) | 31.8 | |||
| Brunnstrom et al., 2009 | 524 (d) | 42.0 | 21.6 | 23.7 | 0.2 | 4.0 | 8.6 | ||
| Schneider et al., 2007a | 141 (35% d) | 82.7 | 30 | 38 | 12 | 12 | |||
AD, Alzheimer disease; CVL, cerebrovascular lesion; LBD, Lewy body disease; VaD, “pure” vascular dementia; d, demented.
*
AD + other pathologies and other dementing disorders are not included.