Table 5.
Types of dementia in oldest-old subjects—autopsies.
| % of total autopsy cases of each cohort | |||||||
|---|---|---|---|---|---|---|---|
| Author | n | Mean age (years) | AD | VD | MIX | DLB | Others |
| Mizutani and Shimada, 1992 | 27 | (100–106) | 33.3 | 18.5 | 22.0 | 15.0 | 12.0 |
| Seno et al., 1999 | 122 | 83.6 ± 8.2 | 34 | 35 | 11 | − | 20 |
| Akatsu et al., 2002 | 158 | 72–91 | 46 | 22 | 2 | 18 | 12 |
| Riekse et al., 2004 | 270 | 80.7 ± 5.6 | 12 (70%F) | 7 (30%F) | ? | ? | ? |
| White et al., 2005 | 363 | 85.5 | 19 | 27.5 | 39.5a | 14b | |
| Jicha et al., 2006 | 34 | 89.0 | 64.7 | 11.7 | 6.0 | 17.6 | 0 |
| Bacchetta et al., 2007 | 110 | 90+ | 23.6 | 32.7 | 46.4 | − | − |
| Schneider et al., 2007a | 141 | 86 | 26 | 16 | 86c | 17 | ? |
| Grinberg et al., 2009 | 206 | 75.6 | 33.6 | 46.8 | 22.4 | − | − |
| Jellinger, 2008b | 1680 | 83.3 ± 5.6 | 46.4/21.0c | 13.1 | 4.8 | 8.5 | 6.3 |
| Jellinger, 2009b | 300 | 90+ | 41/32 | 9 | 12 | 4 | 2 |
| Schneider et al., 2009a | |||||||
| Community cohort | 194 | 89.8 ± 5.5 | 49.45 | 39.2 | 44.3 | 24.7 | 1.5 |
| Clinical cohort | 280 | 79.2 ± 10 | 66.1 | 17.9 | 27.5 | 21.4 | 6.1 |
| Schneider et al., 2009b | 179 | 89.7 ± 56 | 57.5 | 4.5 | 30.2 | 1.1 | 6.2 |
| Brayne et al., 2009 | 113 | 91 (81–101) | 67 | 35 | 26 | 5 | ? |
| White, 2009 | 183 | 72–90+ | 18.6 | 33.8 | 14.2 | 10.9 | 22.5 |
| Jellinger and Attems, 2010a | 1700 | 84.3 ± 5.6 | 45.7/25.0c | 12.8 | 5.7 | 10.7d | 4.2 |
| Echavarri et al., 2012 | 200 | 78.7 | 26 | 2.0 | 28 | 0.5 | 47.5 |
| Corrada et al., 2012 | 63 | 94 (90–104) | 57 | 13.0 | 13.0 | 17.0 | |
20.5% AD + CVLs, 10% Lewy neurites, 9% hippocampal sclerosis;
no cause of dementia identified;
AD + CVLs;
AD + LBs, AD, Alzheimer's disease.
VD, vascular dementia; MIX, mixed dementia (AD + cerebrovascular encephalopathy), CVD, cerebrovascular dementia; DLB, dementia with Lewy bodies; CVLs cerebrovascular lesions; LBs, Lewy bodies.