Fig. 3.—

ξ for indels and single-nucleotide substitutions. Low values of ξ correspond to a high fraction of deleterious mutations and vice versa. (A) Mean ξ in different genome compartments: exons (inframe indels or missense substitutions), intergenic regions, long introns (>300 nt), and short introns (70–300 nt). (B) ξ for indel mutations in short and very short introns, depending on the length of the intron after the indel. Light gray, insertions; dark gray, deletions; yellow, missense substitutions; and blue, single-nucleotide substitutions in noncoding regions. Error bars are 95% confidence intervals based on 1,000 bootstrap trials.