TABLE 1.

Biological functions of miRNAs in the HDL pathway

miRNA	mRNA Target	Biological Pathway Targeted
miR-122	GYS1 (12), SLCA7 (12), ALDOA (12–14), CCNG1 (12), P4HA1 (12), NDRG3 (13), BCKDK (13), CD320 (13), and HCV (15)	Cholesterol and fatty acid synthesis, plasma cholesterol, hepatatis C virus accumulation
miR-33	ABCA1 (19–22, 24, 26), ABCG1 (19, 21), NPC1 (21), CROT (23, 24), CPT1A (23, 24), HADBH (23, 24), IRS2 (23), PRKAA1 (23), ABCB11 (25), and ATP8B1 (25)	HDL biogenesis, cholesterol efflux, RCT, hepatic bile metabolism, pancreatic islet cholesterol metabolism
miR-758	ABCA1, SLC38A1, NTM, STXBP1, EPHA7, and IGF1 (28)	Cholesterol efflux in macrophages and neuroglioma cells, amino acid synthesis
miR-106b	ABCA1 (27)	Cholesterol efflux in neuronal cells
miR-26	ABCA1 (29) and ARL7 (29)	Cholesterol efflux in macrophages
miR-125a miR-455	SR-BI (31)	SR-BI-mediated HDL clearance
miR-223	RhoB and EFNA1 (32)	Most abundant HDL-carried miRNA, posttranscriptional regulation in recipient cells