TABLE 1.
GSEA for myocardial transcriptome changes in the inducible Taz KD model of Barth syndrome
| Gene Set Name (Number of Genes in Pathway) | Number of Genes Overlapped | P |
| Increased gene expression | ||
| Cytosolic tRNA aminoacylation [Reactome] (23) | 11 | 5.15 e−11 |
| tRNA aminoacylation [Reactome] (40) | 11 | 5.28 e−8 |
| Aminoacyl tRNA biosynthesis [KEGG] (41) | 11 | 7 e−8 |
| Translation [Reactome] (120) | 12 | 7.24 e−4 |
| Peptide chain elongation [Reactome] (84) | 9 | 2.06 e−3 |
| Metabolism of nucleotides [Reactome] (71) | 8 | 2.63 e−3 |
| Purine metabolism [Reactome] (30) | 5 | 3.07 e−3 |
| Gene expression [Reactome] (425) | 25 | 4.78 e−3 |
| Valine, leucine, and isoleucine biosynthesis [KEGG] (11) | 3 | 5.21 e−3 |
| Amino acid synthesis and interconversion [Reactome] (12) | 3 | 6.77 e−3 |
| P53 hypoxia pathway [BioCarta] (23) | 4 | 6.89 e−3 |
| Viral mRNA translation [Reactome] (84) | 8 | 7.39 e−3 |
| GTP hydrolysis and Joining of the 60S Ribosomal Subunit | 9 | 9.65 e−3 |
| Ribosome [KEGG] (88) | 8 | 9.71 e−3 |
| Metabolism of proteins [Reactome] (215) | 14 | 1.44 e−2 |
| Formation of a pool of free 4E 40S subunits [Reactome] (95) | 8 | 1.5 e−2 |
| P53 pathway [BioCarta] (16) | 3 | 1.56 e−2 |
| ONE carbon pool of folate [KEGG] (17) | 3 | 1.85 e−2 |
| Unfolded protein response [Reactome] (19) | 3 | 2.5 e−2 |
| ATM pathway [BioCarta] (20) | 3 | 2.87 e−2 |
| EIF4 pathway [BioCarta] (24) | 3 | 4.62 e−2 |
| Decreased gene expression | ||
| Branched chain amino acid catabolism [Reactome] (17) | 3 | 1.17 e−2 |
| IL12 pathway [BioCarta] (23) | 3 | 2.69 e−2 |
| Biopeptides pathway [BioCarta] (43) | 4 | 3.38 e−2 |
| Valine, leucine, isoleucine degradation [KEGG] (44) | 4 | 3.64 e−2 |
| CREB pathway [BioCarta] (27) | 3 | 4.09 e−2 |
Data analyzed from GSE33452 using GSEA.