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. 2013 May;54(5):1448–1456. doi: 10.1194/jlr.M036533

Fig. 5.

Fig. 5.

The protective effects of 11,12-EET on Ang II-induced inflammatory responses is mediated by PPARγ activation in VSMCs. A: 11,12-EET (100 nmol/l) incubation markedly increased PPARγ expression and restored Ang II-induced (10 μmol/l) PPARγ reduction in VSMCs. B, C: 11,12-EET reduced Ang II-induced nuclear NF-κB p65 expression and cytosolic IκBα degradation, while PPARγ antagonist GW9662 (1 μmol/l) markedly inhibited these protective effects. D: ELISA analysis showed that 11,12-EET prevented Ang II-induced IL-6 and MCP-1 expression, but GW9662 (1 μmol/l) significantly blocked this effect (n = 3 for each experiment; **P < 0.01 vs. control; ††P < 0.01 vs. Ang II; ‡‡P < 0.01 vs. Ang II + 11,12-EET).