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. 2013 May;54(5):1448–1456. doi: 10.1194/jlr.M036533

Fig. 6.

Fig. 6.

CYP2J2 overexpression and 11,12-EET suppressed Ang II-induced macrophage migration is through reducing MCP-1 release via PPARγ activation. A: rAAV-CYP2J2 transfection reduced Ang II-induced (10 μmol/l) macrophage migration, and CYP2J2 inhibitor C26 (10 μmol/l) prevented this effect. B: Neutralizing antibody against MCP-1 (10 μg/ml) suppressed the chemotactic effect of Ang II on macrophage. C: PPARγ antagonist GW9662 (1 μmol/l) blocked the antichemotactic effect of 11,12-EET on Ang II-induced macrophage migration [n = 3 for each experiment; **P < 0.01 vs. control; ††P < 0.01 vs. Ang II + rAAV-GFP in (A), Ang II + IgG in (B), or Ang II in (C); ‡‡P < 0.01 vs. Ang II + rAAV-CYP2J2 in (A) or Ang II + 11,12-EET in (C)].