TABLE 2.

Associations of FADS1 rs174550 with erythrocyte PUFAs

	Beijing		Shanghai		Total
Fatty Acid (% wt of total FA)	β (SE)	P	β (SE)	P	β (SE)	P	P for Heterogeneity
18:2n-6	0.81 (0.08)	2.01 × 10−25	0.77 (0.08)	2.70 × 10−24	0.79 (0.06)	5.11 × 10−48	0.73
20:2n-6	0.028 (0.002)	1.91 × 10−32	0.026 (0.002)	3.05 × 10−38	0.027 (0.001)	7.91 × 10−69	0.54
22:2n-6	0.004 (0.0007)	4.36 × 10−9	0.005 (0.0006)	4.66 × 10−16	0.005 (0.0005)	4.77 × 10−23	0.31
18:3n-6	−0.022 (0.003)	5.06 × 10−16	−0.035 (0.002)	1.70 × 10−49	−0.029 (0.006)	2.98 × 10−6	0.0007
20:3n-6	0.25 (0.010)	1.17 × 10−145	0.17 (0.009)	2.08 × 10−82	0.21 (0.04)	8.30 × 10−7	8.70 × 10−11
20:4n-6	−0.97 (0.06)	9.66 × 10−59	−0.87 (0.06)	8.82 × 10−52	−0.92 (0.05)	1.01 × 10−73	0.22
22:4n-6	−0.21 (0.02)	2.77 × 10−27	−0.16 (0.02)	7.25 × 10−21	−0.19 (0.03)	8.97 × 10−11	0.03
22:5n-6	−0.002 (0.012)	0.87	0.021 (0.012)	0.07	0.010 (0.008)	0.26	0.18
18:3n-3	0.07 (0.02)	0.0008	0.10 (0.02)	6.04 × 10−7	0.08 (0.02)	3.02 × 10−7	0.25
EPA	−0.025 (0.005)	9.11 × 10−7	−0.050 (0.007)	6.58 × 10−11	−0.04 (0.01)	0.003	0.006
22:5n-3	−0.06 (0.01)	2.70 × 10−8	−0.07 (0.01)	1.98 × 10−13	−0.07 (0.01)	1.86 × 10−13	0.21
DHA	−0.023 (0.03)	0.45	0.002 (0.03)	0.96	−0.01 (0.02)	0.60	0.58
20:4n-6/20:3n-6	−2.39 (0.08)	7.73 × 10−189	−1.98 (0.07)	2.51 × 10−175	−2.18 (0.20)	1.89 × 10−26	0.0001

18:3n-3 was log-transformed before analyses. βs (SE) are expressed as changes in the levels of PUFA or their ratio for increasing copy of FADS1 rs174550 C-allele in the total population. P values are adjusted for age, sex, BMI, and residence (urban/rural) using an additive model. Random-effect model was used in the meta-analysis.