TABLE 3.

Associations of FADS1-rs174550 with lipids

	Beijing		Shanghai		Total
	β (SE)	P	β (SE)	P	β (SE)	P	P for Heterogeneity
Total cholesterol (mmol/l)
Model 1a	0.003 (0.041)	0.95	−0.061 (0.032)	0.06	−0.037 (0.025)	0.14	0.22
Model 2b	0.021 (0.041)	0.62	−0.048 (0.033)	0.15	−0.021 (0.026)	0.42	0.19
Model 3c	−0.018 (0.044)	0.68	−0.078 (0.035)	0.02	−0.055 (0.027)	0.05	0.29
HDL cholesterol (mmol/l)
Model 1a	−0.009 (0.014)	0.50	−0.030 (0.012)	0.009	−0.021 (0.009)	0.02	0.25
Model 2b	−0.006 (0.014)	0.69	−0.023 (0.012)	0.05	−0.016 (0.009)	0.08	0.36
Model 3c	0.020 (0.015)	0.17	−0.019 (0.013)	0.13	−0.002 (0.010)	0.82	0.05
LDL cholesterol (mmol/l)
Model 1a	0.008 (0.041)	0.84	−0.029 (0.031)	0.36	−0.016 (0.025)	0.53	0.47
Model 2b	0.023 (0.041)	0.58	−0.020 (0.032)	0.53	−0.004 (0.025)	0.88	0.41
Model 3c	0.015 (0.044)	0.73	−0.032 (0.034)	0.34	−0.014 (0.027)	0.59	0.40
Triglycerides (mmol/l)
Model 1a	0.092 (0.025)	0.0002	0.024 (0.020)	0.22	0.056 (0.034)	0.10	0.03
Model 2b	0.096 (0.025)	0.0001	0.025 (0.020)	0.21	0.059 (0.035)	0.10	0.03
Model 3c	−0.004 (0.025)	0.88	−0.022 (0.021)	0.29	−0.015 (0.016)	0.37	0.58

βs (SE) were expressed as changes in blood lipids for increasing copy of FADS1 rs174550 C-allele. Triglyceride was log-transformed before analyses. βs (SE) and corresponding P values were adjusted for covariates using an additive model. Random-effect model was used in the meta-analysis.

^aAdjusted for age, sex, BMI, and residence (urban/rural).

^bModel 1 further adjusted for EPA.

^cModel 1 further adjusted for 20:4n-6.