TABLE 5.
Interactions of 18:2n-6 and 18:3n-3 with FADS1 rs174550 genotypes on erythrocyte PUFA
| Low |
High |
||||||||
| Erythrocyte PUFAs (%) | TT | TC | CC | P | TT | TC | CC | P | P for Interaction |
| 18:2 n-6 | 11.7 ± 0.1 | 12.1 ± 0.1 | 12.2 ± 0.1 | 16.0 ± 0.1 | 16.3 ± 0.1 | 16.8 ± 0.1 | |||
| 20:4n-6 | 13.58 ± 0.06 | 12.82 ± 0.07 | 11.91 ± 0.15 | 7.38 × 10−31 | 13.41 ± 0.06 | 12.59 ± 0.05 | 11.42 ± 0.08 | 1.14 × 10−79 | 0.47 |
| 18:3 n-3 | 0.18 ± 0.001 | 0.19 ± 0.002 | 0.20 ± 0.003 | 0.35 ± 0.01 | 0.36 ± 0.01 | 0.36 ± 0.01 | |||
| EPA | 0.46 ± 0.01 | 0.43 ± 0.01 | 0.38 ± 0.02 | 5.17 × 10−7 | 0.45 ± 0.01 | 0.45 ± 0.01 | 0.40 ± 0.01 | 8.07 × 10−13 | 0.09 |
| DHA | 4.54 ± 0.03 | 4.49 ± 0.04 | 4.49 ± 0.08 | 0.38 | 4.30 ± 0.04 | 4.29 ± 0.04 | 4.33 ± 0.06 | 0.83 | 0.96 |
Data are means ± SE. P values were adjusted for age, sex, BMI, residence (urban/rural), and region (Beijing/Shanghai) using an additive model. Low and high groups are stratified by medians of erythrocyte 18:2n-6 and 18:3n-3 (in bold), respectively.