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CB-PIC (0 or 40 μg/mL) was treated under normoxic or hypoxic conditions for various times (0, 0.5, 1, 2, 4, or 6 hrs). Western blotting was performed to determine HIF-1α, AMPKα, pAMPKα, pERK, ERK, and β-actin expressions. (a) CB-PIC dramatically induces hypoxia-induced pAMPKα and pERK expressions and decreases hypoxia inducible factor 1α (HIF-1α) accumulation in SW620 cells under hypoxia as time-dependent manner. (b) CB-PIC induced pAMPKα, and pERK expression was increased.
