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Schematic representation of transcriptional gene repression by enhancer of zeste homolog 2 (EZH2). Proposed mechanism leads to aberrantly high levels of trimethylation on histone H3K27 in cancer.
Abbreviations: EED, embryonic ectoderm development; EZH2, enhancer of zeste homolog 2; RbAP46/48, retinoblastoma-associated protein 46/48; SUZ12, suppressor of zeste 12 homolog.
