TABLE 3.

SNPs HIGHLY ASSOCIATED WITH CIRCULATING CC16 LEVELS AND SP-D LEVELS OF SUBJECTS WITH COPD

	SNP	Rank	P	CHR	Coordinate	Type	Closest Gene	Distance to Gene	Minor Allele	MAF	HWE
CC16	rs3741240	1	1.42 × 10−26	11	62186542	5′ UTR	SCGB1A1	0	A	0.36	0.05
	rs2077224	2	1.67 × 10−14	11	62197427	Downstream	AHNAK	3,589	A	0.38	0.63
	rs2509956	3	1.03 × 10−13	11	62196723	Downstream	AHNAK	4,293	C	0.37	0.96
	rs10836312	4	6.72 × 10−11	11	34810443	Intergenic	APIP	93,402	C	0.41	0.93
	rs2463822	5	1.02 × 10−10	11	62103420	Upstream	ASRGL1	−1,354	T	0.12	1
	rs906902	6	2.42 × 10−10	11	34780278	Intergenic	EHF	97,197	A	0.40	0.82
	rs10466455	7	2.63 × 10−10	11	34780936	Intergenic	EHF	97,855	C	0.40	0.85
	rs2463836	8	3.11 × 10−10	11	62126494	Intronic	ASRGL1	0	A	0.12	1
	rs2246920	9	3.48 × 10−10	11	62104937	Regulatory region; 5′ UTR	ASRGL1	0	T	0.12	1
	rs17157266	10	1.29 × 10−09	11	62199817	Downstream	AHNAK	1,199	C	0.18	0.07
	rs7929679	11	7.26 × 10−09	11	34805849	Intergenic	APIP	97,996	G	0.49	0.72
SP-D	rs1885551	1	1.16 × 10−39	10	81712353	Intronic	SFTPD	0	G	0.10	0.39
	rs2146192	2	1.16 × 10−39	10	81715738	Intronic	SFTPD	0	C	0.10	0.39
	rs7084667	3	1.14 × 10−29	10	81748708	Intergenic	SFTPD	−5,712	T	0.34	0.72
	rs3923564	4	1.76 × 10−27	10	81735981	Intronic	SFTPD	0	G	0.04	1
	rs1885553	5	5.33 × 10−21	10	81711711	Intronic	SFTPD	0	C	0.33	0.69
	rs1932571	6	5.37 × 10−20	10	81761489	Intergenic	RP11-369J21.6	15,944	T	0.18	0.22
	rs7905482	7	8.37 × 10−15	10	81863964	Intergenic	RP11-369J21.2	11,651	T	0.36	0.30
	rs911887	8	7.15 × 10−14	10	81701523	Intronic	SFTPD	0	C	0.42	0.75
	rs12778754	9	2.19 × 10−13	10	81869642	Intergenic	RP11-369J21.4	−16,055	A	0.31	0.27
	rs8048576	10	8.96 × 10−13	16	84423034	Intronic	ATP2C2	0	A	0.12	0.92
	rs728616	11	2.02 × 10−12	10	81847914	Intronic	RP11-369J21.2	0	T	0.08	0.75
	rs3851050	12	1.27 × 10−11	10	81882370	Upstream	RP11-369J21.4	−3,327	C	0.41	0.43
	rs1265110	13	2.76 × 10−11	6	31119422	Intronic	CCHCR1	0	T	0.11	0.49
	rs12220777	14	6.69 × 10−11	10	81788104	Upstream	RP11-369J21.5	−3,189	C	0.08	7.3 × 10−6
	rs6585424	15	1.38 × 10−10	10	81933748	Intronic	ANXA11	0	G	0.13	0.48
	rs6585454	16	1.38 × 10−10	10	81940701	5′ UTR	ANXA11	0	G	0.13	0.48
	rs8063863	17	1.56 × 10−10	16	84400850	Upstream	ATP2C2	−1,283	T	0.15	0.41
	rs2074488	18	2.28 × 10−10	6	31240431	Upstream	HLA-C	−524	T	0.13	0.85
	rs9266629	19	3.99 × 10−10	6	31346822	Upstream	FGFR3P	1,026	C	0.21	0.11
	rs11201799	20	1.44 × 10−09	10	81881954	Upstream	RP11-369J21.4	−3,743	A	0.09	0.40
	rs7078012	21	4.95 × 10−09	10	81705433	Intronic	SFTPD	0	T	0.13	0.06
	rs1923539	22	5.03 × 10−09	10	81694950	Within noncoding gene	RP11-479O17.4	0	A	0.25	0.60
	rs1265093	23	5.78 × 10−09	6	31107187	Intronic	PSORS1C1	0	A	0.26	0.27
	rs3130559	24	8.34 × 10−09	6	31097301	Intronic	PSORS1C1	0	T	0.20	0.63

Definition of abbreviations: CC16 = Clara cell secretory protein; CHR = chromosome; COPD = chronic obstructive pulmonary disease; HWE = P value for deviation from Hardy-Weinberg equilibrium; MAF = minor allele frequency; SNP = single nucleotide polymorphisms; SP-D = surfactant protein D.