TABLE 4.

THE ASSOCIATION OF SNPs AFFECTING BLOOD CC16 LEVELS WITH THE LEVELS OF mRNA EXPRESSION OF SCGB1A1 IN SPUTUM

Genome-Wide Significant SNPs Affecting Blood CC16 Levels					Association with mRNA Expression of SCGB1A1 in Sputum
CHR	SNP	BP	Minor Allele	Nearest Gene	Beta	95% CI	P
11	rs10466455	34737512	C	EHF	−0.65	−1.12 to −0.17	0.009
11	rs10836312	34767019	C	APIP	−0.65	−1.12 to −0.17	0.009
11	rs906902	34736854	A	EHF	−0.65	−1.12 to −0.17	0.009
11	rs3741240	61943118	A	SCGB1A1	−0.52	−0.96 to −0.09	0.020
11	rs2509956	61953299	C	AHNAK	−0.55	−1.05 to −0.05	0.034

Definition of abbreviations: Beta = regression coefficient; BP = physical position (base pair); CC16 = Clara cell secretory protein; CHR = chromosome; CI = confidence interval (lower, upper); SNP = single nucleotide polymorphism.

The linear models were adjusted for age, sex, pack-years, current smoking status, and principal components for genetic ancestry.

Only SNPs with P < 0.05 are shown.