TABLE 5.

THE ASSOCIATION OF SNPs AFFECTING BLOOD SP-D LEVELS WITH mRNA EXPRESSION OF SFTPD IN SPUTUM

Genome-Wide Significant SNPs Affecting Blood SP-D Levels					Association with mRNA Expression of SFTPD in Sputum
CHR	SNP	BP	Minor Allele	Nearest Gene	Beta	95% CI	P
10	rs1923539	81684930	A	RP11-479O17.4	0.09	−0.001 to 0.17	0.055
10	rs1885551	81702333	G	SFTPD	0.10	−0.005 to 0.20	0.065
10	rs2146192	81705718	C	SFTPD	0.10	−0.005 to 0.20	0.065

Definition of abbreviations: Beta = regression coefficient; BP = physical position (base-pair); CHR = chromosome; CI = confidence interval (lower, upper); SNP = single nucleotide polymorphism; SP-D = surfactant protein D.

The linear models were adjusted with age, sex, pack-years, current smoking status, and principal components for genetic ancestry.

No SNPs with P < 0.05 were observed; SNPs close to P = 0.05 are shown even though they are not statistically significant.