TABLE 6.

THE ASSOCIATION OF TOP BIOMARKER GWAS SNPs WITH RISK OF COPD IN THE COMBINED COLLABORATIVE COPD GWAS MEGA-ANALYSIS

Protein	CHR	SNP	BP	Nearest Gene	Minor Allele	Test	OR	95% CI	P*
CC16	11	rs17157266	61956393	AHNAK	C	ADD	1.20	1.05 to 1.37	0.008
Surfactant protein D	16	rs8063863	82958351	ATP2C2	T	ADD	0.80	0.70 to 0.92	0.001
	16	rs8048576	82980535	ATP2C2	A	ADD	0.82	0.71 to 0.95	0.008
	10	rs7078012	81695413	SFTPD	T	ADD	0.84	0.73 to 0.97	0.017
	10	rs1885553	81701691	SFTPD	C	ADD	1.11	1.00 to 1.24	0.049
	10	rs1923539	81684930	RP11-479O17.4	A	ADD	1.13	1.00 to 1.27	0.043

Definition of abbreviations: BP = physical position (base-pair); CC16 = Clara cell secretory protein; CHR = chromosome; CI = confidence interval (lower, upper); COPD = chronic obstructive pulmonary disease; GWAS = genome-wide association study; OR = odds ratio; SNP = single nucleotide polymorphism.

Only SNPs with P < 0.05 are shown.

^*P values adjusted for age, pack-years of smoking, and 16 principal components for genetic ancestry.